Talk:Mass spectrometry
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This is the discussion page for the article Mass spectrometry. It is for improving the article: sources, wording, structure, scope and titles. It is not a general discussion forum about the subject, and it is not a place to ask for advice — see Project:Medical disclaimer.
Deamidation and unit resolutionResolved
The 0.984 Da point is the most practically important thing here. A quadrupole simply cannot see deamidation on a 4 kDa peptide, and reports frequently do not say what instrument was used. — MassSpecMarv (talk) 10:15, 7 February 2026 (UTC)
Added a sentence saying a report without the instrument resolution understates the ambiguity. That is checkable from the document. ✓ Done — Chromatokid (talk) 13:50, 7 February 2026 (UTC)
Stereochemistry gap
Worth noting that racemisation is most likely at histidine and cysteine under standard coupling conditions, so the gap is not uniform across a sequence. — AAA_Analyst (talk) 09:35, 29 April 2026 (UTC)
True, but that is synthesis detail and belongs at Solid-phase peptide synthesis. Here the point is only that mass cannot see it at all. — FmocFrancis (talk) 13:10, 29 April 2026 (UTC)
Poorly ionising impuritiesDone
The closing point — that absence from a spectrum is not absence from the material — mirrors the equivalent caution on the chromatography article. Consistency between the two is good. — SigFigSindri (talk) 11:20, 3 June 2026 (UTC)
Deliberately parallel. Every detector has a blind spot and the reader should expect the caveat wherever a detector appears. ✓ Done — MassSpecMarv (talk) 14:45, 3 June 2026 (UTC)