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Talk:High-performance liquid chromatography

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This article is within the scope of the analytical working group.
Rated A-class. Heavily linked; keep it a survey and push detail to the specific articles.

This is the discussion page for the article High-performance liquid chromatography. It is for improving the article: sources, wording, structure, scope and titles. It is not a general discussion forum about the subject, and it is not a place to ask for advice — see Project:Medical disclaimer.

Orthogonal method paragraphResolved

The observation that analysing with a method derived from the purification separation flatters the result is the sort of thing that never appears in secondary sources. Worth keeping and worth expanding at Analytical method validation. — ResolutionRoo (talk) 10:40, 13 March 2026 (UTC)

Expanded there under specificity. Here it stays at one paragraph. ✓ Done — PrepHPLC_Pia (talk) 14:15, 13 March 2026 (UTC)

Resolved. This thread is closed. Reopening it is fine if new sources appear; please add a new subsection rather than editing the closed discussion.

Should sub-2-micron particles be covered?

The article mentions them in passing. Given how much modern peptide work runs on them, is a subsection warranted? — ColumnOvenCoy (talk) 11:05, 20 May 2026 (UTC)

I would rather not. The instrumentation detail does not change how a reader interprets a certificate, which is what this article is for. — GradientGus (talk) 14:40, 20 May 2026 (UTC)

This page was last edited on 20 May 2026, by GradientGus. Text is available under the PeptidePedia Wiki Content Licence (PPCL-BY-SA 4.0).