Proglucagon: difference between revisions
Diff·revision 15 → 16·17:42, 23 Jan 2025
Difference between revision 15 and revision 16 of Proglucagon. 5 lines changed; the page grew by 742 bytes.
| Revision 15 — 04:29, 3 Jan 2025 PharmDrafts (talk) clarify that the receptor is expressed outside the pancreas 4,256 bytes ±0 | Revision 16 — 17:42, 23 Jan 2025 ThymosinTamsin (talk) rm the sentence implying the hormone is a drug 4,998 bytes +742 | ||
|---|---|---|---|
| 35 | The boundaries are not absolute. Alpha cells upregulate PC1/3 under metabolic stress and can secrete GLP-1 directly, a phenomenon described in islets from donors with type 2 diabetes and in rodent models of beta-cell injury. The physiological importance of islet-derived GLP-1 in humans is debated; the quantities are small relative to intestinal secretion but are delivered locally, where concentration at the receptor may matter more than circulating concentration.{{r|campbell2013}} | 35 | The boundaries are not absolute. Alpha cells upregulate PC1/3 under metabolic stress and can secrete GLP-1 directly, a phenomenon described in islets from donors with type 2 diabetes and in rodent models of beta-cell injury. The physiological importance of islet-derived GLP-1 in humans is debated; the quantities are small relative to intestinal secretion but are delivered locally, where concentration at the receptor may matter more than circulating concentration.{{r|campbell2013}} |
| 36 | 36 | ||
| + | 37 | Oxyntomodulin, a 37-residue product of L-cell processing, is a weak agonist at both the glucagon receptor and the [[GLP-1 receptor]]. It is the natural template for the dual glucagon/GLP-1 agonists now in development, and its existence is why such a molecule was thought plausible in the first place.{{r|sandoval2015}} | |
| + | 38 | ||
| + | 39 | == Consequences for measurement == | |
| + | 40 | Immunoassays for the products of proglucagon are notoriously cross-reactive. Antisera raised against the C-terminus of glucagon detect glicentin and oxyntomodulin, both of which contain the glucagon sequence; assays raised against the N-terminus detect the major proglucagon fragment. Reported fasting glucagon concentrations vary several-fold between published methods.{{r|holst2007}} | |
| + | 41 | ||
| 37 | == References == | 42 | == References == |
| 38 | {{reflist}} | 43 | {{reflist}} |