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TRIUMPH trial programme (revision 1)

Old revision·06:20, 18 Sep 2024·FreightFenna

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TRIUMPH trial programme
DrugRetatrutide
Indications studiedObesity, type 2 diabetes, related conditions
StatusOngoing; not approved
Topic infobox · conventions

The TRIUMPH trial programme is the phase 3 series evaluating retatrutide, an investigational triple agonist at the GIP, GLP-1 and glucagon receptors. The compound is not approved in any jurisdiction and the programme is ongoing.[1]

The programme follows a phase 2 obesity trial that reported mean weight change of −24.2% at 48 weeks at the highest dose against −2.1% for placebo. Phase 2 effect sizes in this field have not always been reproduced at phase 3 scale, and this article will require revision as the programme reports.[1]

References

  1. ^ a b Jastreboff AM, Kaplan LM, Frías JP, et al. "Triple-hormone-receptor agonist retatrutide for obesity — a phase 2 trial." New England Journal of Medicine 389(6):514–526 (2023). DOI:10.1056/NEJMoa2301972. PMID 37366315.