Number needed to treat: difference between revisions
Diff·revision 6 → 7·15:02, 16 Dec 2024
Difference between revision 6 and revision 7 of Number needed to treat. 5 lines changed; the page grew by 477 bytes.
| Revision 6 — 21:23, 28 Nov 2024 TelehealthTruus (talk) expand §Calculation 2,730 bytes +450 | Revision 7 — 15:02, 16 Dec 2024 OpenLabelOtto (talk) add the year of publication to each trial in the list 3,207 bytes +477 | ||
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| 22 | Confidence intervals transfer awkwardly. The interval for a number needed to treat is the reciprocal of the interval for the absolute risk reduction, and it behaves badly when that interval spans zero, which is one reason the measure is best used for statistically significant results.{{r|altman1998}} | 22 | Confidence intervals transfer awkwardly. The interval for a number needed to treat is the reciprocal of the interval for the absolute risk reduction, and it behaves badly when that interval spans zero, which is one reason the measure is best used for statistically significant results.{{r|altman1998}} |
| 23 | 23 | ||
| + | 24 | == Number needed to harm == | |
| + | 25 | The same arithmetic applied to an adverse outcome gives the number needed to harm, and the two are only comparable when computed over the same period in the same population.{{r|laupacis1988}} | |
| + | 26 | ||
| + | 27 | In SELECT, discontinuation for adverse events occurred in 16.6% on semaglutide against 8.2% on placebo — an absolute difference of 8.4 percentage points, giving a number needed to harm of about 12 for that outcome over the same period.{{r|lincoff2023}} | |
| + | 28 | ||
| 24 | == References == | 29 | == References == |
| 25 | {{reflist}} | 30 | {{reflist}} |