Missed dose (revision 2)
Old revision·20:01, 29 Sep 2024·MicrodoseMagnus
This is an old revision of this page, as it stood at 20:01, 29 Sep 2024, saved by MicrodoseMagnus with the summary add the note about drawing air before withdrawal. It may differ substantially from the current revision, and any error it contains may since have been corrected.
| Missed dose | |
|---|---|
| Governing quantity | Half-life relative to dosing interval |
| Weekly agents | Long half-life; concentration falls slowly |
| Daily agents | Steady state re-established within days |
| Topic infobox · conventions | |
A missed dose is a scheduled administration that is not taken. How much it matters depends almost entirely on the ratio between the drug's half-life and its dosing interval: a long half-life relative to the interval means concentrations fall slowly and a single omission changes exposure little.[1]
For a weekly agent with a half-life of several days, the concentration at the end of a normal dosing interval has fallen to a substantial fraction of its peak, and a missed week extends that decline rather than producing a sudden loss of exposure. For a daily agent with a half-life of hours, a missed day is a larger proportional change but is corrected within a day or two of resuming.[2]
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