Missed dose (revision 1)
Old revision·02:11, 26 Sep 2024·FootnoteFyfe
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| Missed dose | |
|---|---|
| Governing quantity | Half-life relative to dosing interval |
| Weekly agents | Long half-life; concentration falls slowly |
| Daily agents | Steady state re-established within days |
| Topic infobox · conventions | |
A missed dose is a scheduled administration that is not taken. How much it matters depends almost entirely on the ratio between the drug's half-life and its dosing interval: a long half-life relative to the interval means concentrations fall slowly and a single omission changes exposure little.[1]
For a weekly agent with a half-life of several days, the concentration at the end of a normal dosing interval has fallen to a substantial fraction of its peak, and a missed week extends that decline rather than producing a sudden loss of exposure. For a daily agent with a half-life of hours, a missed day is a larger proportional change but is corrected within a day or two of resuming.[2]
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