Methionine oxidation: difference between revisions
Diff·revision 4 → 5·20:51, 16 Dec 2024
Difference between revision 4 and revision 5 of Methionine oxidation. 3 lines changed; the page grew by 362 bytes.
| Revision 4 — 16:00, 7 Dec 2024 MolarMassMaeve (talk) expand §Chemistry and promoters 2,318 bytes +246 | Revision 5 — 20:51, 16 Dec 2024 DrTitration (talk) ce per PP:MOS 2,680 bytes +362 | ||
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| 17 | Metal-catalysed oxidation is the more insidious route. Trace iron or copper, in the presence of oxygen and a reducing agent, generates reactive species locally at metal-binding sites, so oxidation can be site-specific rather than uniform. Chelating agents in formulations exist largely to suppress this. | 17 | Metal-catalysed oxidation is the more insidious route. Trace iron or copper, in the presence of oxygen and a reducing agent, generates reactive species locally at metal-binding sites, so oxidation can be site-specific rather than uniform. Chelating agents in formulations exist largely to suppress this. |
| 18 | 18 | ||
| + | 19 | Peroxide contamination of excipients — polysorbates in particular are prone to peroxide formation on storage — is a recognised source in formulated products. For research peptides supplied as unformulated lyophilisates the more likely sources are the drying process, container headspace and light exposure.{{r|usp1503}} | |
| + | 20 | ||
| 19 | == References == | 21 | == References == |
| 20 | {{reflist}} | 22 | {{reflist}} |
| ⋮ | ⋮ | ||
| 25 | [[Category:Peptide degradation]] | 27 | [[Category:Peptide degradation]] |
| 26 | [[Category:Analytical science]] | 28 | [[Category:Analytical science]] |
| + | 29 | [[Category:Impurities and residues]] | |
| 27 | 30 |