Medutest: difference between revisions
Diff·revision 3 → 4·00:44, 22 Aug 2024
Difference between revision 3 and revision 4 of Medutest. 3 lines changed; the page grew by 446 bytes.
| Revision 3 — 15:16, 14 Aug 2024 ToleranceTove (talk) give the fields a compendially-complete certificate would carry 2,091 bytes ±0 | Revision 4 — 00:44, 22 Aug 2024 Chromatokid (talk) add the point that reports reaching this wiki are not a sample of anything 2,537 bytes +446 | ||
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| 15 | The distinction matters more than it is usually given credit for. Purity is an area-normalised figure describing the composition of what was injected; content is a mass figure describing how much peptide is present. A material can be 99% pure and 60% peptide by mass, the balance being water, counterion and residual solvent — see [[Trifluoroacetate counterion]] and [[Loss on drying]]. Those two figures answer different questions and neither substitutes for the other. | 15 | The distinction matters more than it is usually given credit for. Purity is an area-normalised figure describing the composition of what was injected; content is a mass figure describing how much peptide is present. A material can be 99% pure and 60% peptide by mass, the balance being water, counterion and residual solvent — see [[Trifluoroacetate counterion]] and [[Loss on drying]]. Those two figures answer different questions and neither substitutes for the other. |
| 16 | 16 | ||
| + | 17 | Where a report and a supplier [[Certificate of analysis|certificate]] both exist for a lot, comparison is only meaningful if the methods are comparable. Two purity figures obtained on different gradients are not directly comparable, and a difference of a few tenths of a percentage point is within ordinary method repeatability.{{r|usp1503,usp621}} | |
| + | 18 | ||
| 17 | == References == | 19 | == References == |
| 18 | {{reflist}} | 20 | {{reflist}} |
| 19 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> | 21 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> |
| 20 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | 22 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> |
| + | 23 | <ref name="usp621">United States Pharmacopeia, General Chapter <621>, ''Chromatography''.</ref> | |
| 21 | 24 | ||
| 22 | {{DEFAULTSORT:Medutest}} | 25 | {{DEFAULTSORT:Medutest}} |