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Insulin syringe unit conversion (revision 16)

Old revision·08:14, 29 Dec 2024·IpamorelinIsold

This is an old revision of this page, as it stood at 08:14, 29 Dec 2024, saved by IpamorelinIsold with the summary British spelling per PP:MOS. It may differ substantially from the current revision, and any error it contains may since have been corrected.
Insulin syringe unit conversion
010203040506070809010042 units = 0.42 mLU-100 insulin syringe, 1 mL barrel
A "unit" is a volume, defined by the syringe, not a quantity of drug.
InputsUnits, millilitres or mass; concentration; syringe scale
OutputsThe other two quantities
Scale definitions
U-100100 units = 1 mL; 1 unit = 0.01 mL
U-5050 units = 0.5 mL; 1 unit = 0.01 mL on a 0.5 mL barrel
U-4040 units = 1 mL; 1 unit = 0.025 mL
StandardISO 8537 (insulin syringes)
Reference tool infobox · conventions

An insulin syringe unit is a graduation on a syringe barrel calibrated for insulin of a stated concentration. On the U-100 scale, which is the international standard for human insulin, 100 units correspond to exactly 1 millilitre, so one unit is 0.01 mL.[1] The unit is therefore a volume, and the mass of any substance it contains depends entirely on the concentration of the solution in the barrel.

This is the single most consequential fact on this page, and the source of the errors it exists to prevent. A "10 unit dose" is a statement about volume; it means 0.1 mL, and it says nothing about milligrams until a concentration is supplied. Where a solution has been reconstituted by the user rather than filled by a manufacturer, no syringe marking can carry information about its strength.

Two other scales remain in circulation. U-50 syringes use a 0.5 mL barrel with the same 0.01 mL graduation, giving finer visual resolution for small volumes. U-40 syringes, still used for veterinary insulin in some jurisdictions, place 40 units in 1 mL, so one unit is 0.025 mL — two and a half times the U-100 unit.[1][2]

The converter

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Enter any one of units, volume or mass together with the solution concentration, and the tool reports the other two on the selected scale.

Scale comparison

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The same barrel reading on three scales
ReadingU-100 volumeU-50 volumeU-40 volume
5 units0.05 mL0.05 mL0.125 mL
10 units0.10 mL0.10 mL0.25 mL
20 units0.20 mL0.20 mL0.50 mL
40 units0.40 mL0.40 mL1.00 mL
50 units0.50 mL0.50 mL (full)
100 units1.00 mL

The U-100 and U-50 columns are identical because both use a 0.01 mL graduation; they differ in barrel capacity and therefore in the physical spacing of the marks, which is the point of the U-50 syringe. The U-40 column is the hazardous one: an identical reading corresponds to two and a half times the volume.

References

  1. ^ a b ISO 8537, Sterile single-use syringes, with or without needle, for insulin. International Organization for Standardization.
  2. ^ US Food and Drug Administration, Center for Veterinary Medicine — guidance on U-40 insulin products and syringe compatibility.