Insulin secretion: difference between revisions
Diff·revision 8 → 9·09:33, 19 Nov 2024
Difference between revision 8 and revision 9 of Insulin secretion. 3 lines changed; the page grew by 469 bytes.
| Revision 8 — 11:31, 3 Nov 2024 ArcuateArt (talk) distinguish the active and total forms of the hormone throughout 3,940 bytes ±0 | Revision 9 — 09:33, 19 Nov 2024 LCellLeif (talk) expand §The triggering pathway 4,409 bytes +469 | ||
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| 26 | Metabolic amplification independent of cAMP also exists: at fixed calcium, raising glucose still increases secretion, an effect attributed to mitochondrially derived coupling factors including NADPH and glutamate. This pathway accounts for a substantial fraction of the total glucose response and is not fully characterised.{{r|rorsman2013}} | 26 | Metabolic amplification independent of cAMP also exists: at fixed calcium, raising glucose still increases secretion, an effect attributed to mitochondrially derived coupling factors including NADPH and glutamate. This pathway accounts for a substantial fraction of the total glucose response and is not fully characterised.{{r|rorsman2013}} |
| 27 | 27 | ||
| + | 28 | Amino acids, free fatty acids acting at FFAR1, and parasympathetic input all amplify. The [[Incretin effect|incretin effect]] — the excess of the oral over the intravenous insulin response — is the integrated ''in vivo'' expression of the hormonal amplifiers.{{r|campbell2013}} | |
| + | 29 | ||
| 28 | == References == | 30 | == References == |
| 29 | {{reflist}} | 31 | {{reflist}} |
| 30 | <ref name="rorsman2013">Rorsman P, Braun M. "Regulation of insulin secretion in human pancreatic islets." ''Annual Review of Physiology'' 75:155–179 (2013). DOI:10.1146/annurev-physiol-030212-183754. PMID 22974438.</ref> | 32 | <ref name="rorsman2013">Rorsman P, Braun M. "Regulation of insulin secretion in human pancreatic islets." ''Annual Review of Physiology'' 75:155–179 (2013). DOI:10.1146/annurev-physiol-030212-183754. PMID 22974438.</ref> |
| 31 | <ref name="drucker2018">Drucker DJ. "Mechanisms of action and therapeutic application of glucagon-like peptide-1." ''Cell Metabolism'' 27(4):740–756 (2018). PMID 29617641.</ref> | 33 | <ref name="drucker2018">Drucker DJ. "Mechanisms of action and therapeutic application of glucagon-like peptide-1." ''Cell Metabolism'' 27(4):740–756 (2018). PMID 29617641.</ref> |
| + | 34 | <ref name="campbell2013">Campbell JE, Drucker DJ. "Pharmacology, physiology, and mechanisms of incretin hormone action." ''Cell Metabolism'' 17(6):819–837 (2013). PMID 23684623.</ref> | |
| 32 | 35 | ||
| 33 | {{DEFAULTSORT:Insulin secretion}} | 36 | {{DEFAULTSORT:Insulin secretion}} |