Injection site rotation: difference between revisions
Diff·revision 8 → 9·16:41, 20 Jan 2025
Difference between revision 8 and revision 9 of Injection site rotation. 13 lines changed; the page grew by 586 bytes.
| Revision 8 — 14:26, 25 Dec 2024 ResinRhoswen (talk) add a second worked example at a different vial strength 2,969 bytes +40 | Revision 9 — 16:41, 20 Jan 2025 NauseaNoor (talk) state the assumption that the whole vial is reconstituted at once 3,555 bytes +586 | ||
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| 20 | Whether repeated weekly injection of a peptide produces the same lesion is not established. Frequency is much lower, but the mechanical and pharmacological insults are qualitatively similar, and the literature on this specific question is thin.{{r|richter2012}} | 20 | Whether repeated weekly injection of a peptide produces the same lesion is not established. Frequency is much lower, but the mechanical and pharmacological insults are qualitatively similar, and the literature on this specific question is thin.{{r|richter2012}} |
| 21 | 21 | ||
| + | 22 | == Rotation schemes == | |
| + | 23 | The schemes described in the insulin literature divide each anatomical region into quadrants or a grid, use one region for a defined period, and move within it by a fixed distance each time before moving to the next region.{{r|ada2024}} | |
| + | 24 | ||
| + | 25 | | Pattern | Effect | | |
| + | 26 | |---|---| | |
| + | 27 | | Within-region, fixed spacing | Spreads mechanical insult; absorption profile stable | | |
| + | 28 | | Between-region each time | Spreads insult; absorption profile varies between doses | | |
| + | 29 | | No rotation | Concentrates insult at one point | | |
| + | 30 | ||
| 22 | == References == | 31 | == References == |
| 23 | {{reflist}} | 32 | {{reflist}} |
| ⋮ | ⋮ | ||
| 25 | <ref name="gentile2016">Gentile S, Strollo F, Ceriello A. "Lipodystrophy in insulin-treated subjects and other injection-site skin reactions: are we sure everything is clear?" ''Diabetes Therapy'' 7(3):401–409 (2016). PMID 27503118.</ref> | 34 | <ref name="gentile2016">Gentile S, Strollo F, Ceriello A. "Lipodystrophy in insulin-treated subjects and other injection-site skin reactions: are we sure everything is clear?" ''Diabetes Therapy'' 7(3):401–409 (2016). PMID 27503118.</ref> |
| 26 | <ref name="richter2012">Richter WF, Bhansali SG, Morris ME. "Mechanistic determinants of biotherapeutics absorption following SC administration." ''The AAPS Journal'' 14(3):559–570 (2012). PMID 22619043.</ref> | 35 | <ref name="richter2012">Richter WF, Bhansali SG, Morris ME. "Mechanistic determinants of biotherapeutics absorption following SC administration." ''The AAPS Journal'' 14(3):559–570 (2012). PMID 22619043.</ref> |
| + | 36 | ||
| + | 37 | == See also == | |
| + | 38 | * [[Subcutaneous injection]] | |
| + | 39 | * [[Insulin syringe]] | |
| 27 | 40 | ||
| 28 | {{DEFAULTSORT:Injection site rotation}} | 41 | {{DEFAULTSORT:Injection site rotation}} |