Glucagon-like peptide-1: difference between revisions
Diff·revision 12 → 13·11:27, 29 Jul 2024
Difference between revision 12 and revision 13 of Glucagon-like peptide-1. 2 lines changed; the page grew by 354 bytes.
| Revision 12 — 05:45, 24 Jul 2024 ColdChainCleo (talk) correct molar mass 3,458 bytes +453 | Revision 13 — 11:27, 29 Jul 2024 ReceptorRhoda (talk) attribute range as a review estimate per talk 3,812 bytes +354 | ||
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| 20 | Proglucagon is encoded by a single gene (''GCG'') and is processed differently in different tissues. In pancreatic alpha cells, prohormone convertase 2 predominates and glucagon is the principal product. In intestinal L cells and in some neurons of the caudal brainstem, prohormone convertase 1/3 predominates and the products are GLP-1, GLP-2 and the glicentin-related fragments.{{r|baggio2007}} | 20 | Proglucagon is encoded by a single gene (''GCG'') and is processed differently in different tissues. In pancreatic alpha cells, prohormone convertase 2 predominates and glucagon is the principal product. In intestinal L cells and in some neurons of the caudal brainstem, prohormone convertase 1/3 predominates and the products are GLP-1, GLP-2 and the glicentin-related fragments.{{r|baggio2007}} |
| 21 | 21 | ||
| + | 22 | L cells are open-type epithelial cells whose apical surface contacts the lumen, giving them direct access to nutrient stimuli. Secretion is biphasic: an early rise within 10–15 minutes of ingestion, attributed partly to neural and endocrine relay from the proximal gut, followed by a later phase as nutrients reach the ileum and colon.{{r|holst2007}} | |
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| 22 | == References == | 24 | == References == |
| 23 | {{reflist}} | 25 | {{reflist}} |