GLP-1 receptor: difference between revisions
Diff·revision 23 → 24·03:49, 24 Jul 2025
Difference between revision 23 and revision 24 of GLP-1 receptor. 2 lines changed; the page grew by 421 bytes.
| Revision 23 — 12:08, 26 Jun 2025 StubSorterBot (talk) bot: expand PMID to full citation 7,149 bytes +118 | Revision 24 — 03:49, 24 Jul 2025 ArcuateArt (talk) add see also to the sister hormone 7,570 bytes +421 | ||
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| 56 | Common coding variants of GLP1R have been associated in genome-wide studies with small differences in fasting glucose and in insulin response to oral glucose. The effect sizes are small relative to the pharmacological effect of an agonist, and no variant has been shown to be useful for predicting response to treatment.{{r|zhang2017}} | 56 | Common coding variants of GLP1R have been associated in genome-wide studies with small differences in fasting glucose and in insulin response to oral glucose. The effect sizes are small relative to the pharmacological effect of an agonist, and no variant has been shown to be useful for predicting response to treatment.{{r|zhang2017}} |
| 57 | 57 | ||
| + | 58 | Rare loss-of-function variants have been described but are not associated with a recognised clinical syndrome, consistent with substantial redundancy in the incretin axis. Whether variation in GLP1R contributes to the wide interindividual spread in weight response to agonists is unresolved; the published attempts to associate genotype with response have been small and have not replicated consistently.{{r|jones2018}} | |
| + | 59 | ||
| 58 | == References == | 60 | == References == |
| 59 | {{reflist}} | 61 | {{reflist}} |