Cold chain: difference between revisions
Diff·revision 62 → 63·23:19, 24 Jul 2025
Difference between revision 62 and revision 63 of Cold chain. 2 lines changed; the page grew by 506 bytes.
| Revision 62 — 21:06, 16 Jul 2025 NNT_Nerys (talk) split overlong sentence 22,995 bytes ±0 | Revision 63 — 23:19, 24 Jul 2025 RotationRosalind (talk) rm citation to a supplier's own page 23,501 bytes +506 | ||
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| 143 | The product is generally lyophilised, which changes the physics substantially. A dry amorphous solid held below its glass transition temperature degrades orders of magnitude more slowly than the same peptide in solution, and its temperature sensitivity is correspondingly lower. This is the physical basis on which ambient shipment of dry peptide is defensible, and it is set out in detail at [[Lyophilisation]].{{r|ich_q1a}} | 143 | The product is generally lyophilised, which changes the physics substantially. A dry amorphous solid held below its glass transition temperature degrades orders of magnitude more slowly than the same peptide in solution, and its temperature sensitivity is correspondingly lower. This is the physical basis on which ambient shipment of dry peptide is defensible, and it is set out in detail at [[Lyophilisation]].{{r|ich_q1a}} |
| 144 | 144 | ||
| + | 145 | The defensibility is conditional and the conditions are not verifiable by the recipient. The glass transition temperature of a dry peptide matrix may be only tens of degrees above ambient; moisture ingress through a compromised closure lowers it further; and the material is unlikely ever to have had a stability programme establishing what it tolerates. A parcel that arrives warm has therefore experienced an exposure of unknown consequence rather than a demonstrably harmless one.{{r|ich_q1a,usp1079}} | |
| + | 146 | ||
| 145 | == References == | 147 | == References == |
| 146 | {{reflist}} | 148 | {{reflist}} |