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Cold chain: difference between revisions

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68The conventional expectation for a logger used in 2–8 °C distribution is an accuracy of ±0.5 °C across that range. This is an expectation drawn from qualification practice and from performance specifications for prequalified devices; it is not a requirement imposed by a general chapter, and articles asserting it as a standard have been corrected on this point.{{r|whotrs961,usp1118}}68The conventional expectation for a logger used in 2–8 °C distribution is an accuracy of ±0.5 °C across that range. This is an expectation drawn from qualification practice and from performance specifications for prequalified devices; it is not a requirement imposed by a general chapter, and articles asserting it as a standard have been corrected on this point.{{r|whotrs961,usp1118}}
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+70Traceability of the record itself is a separate question from calibration of the sensor. A record that cannot be tied to a specific consignment, with the times of custody transfer identified, cannot be used to attribute an excursion to a stage of the chain, which is the purpose for which such records are chiefly wanted.{{r|eugdp2013}}
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70== References ==72== References ==
71{{reflist}}73{{reflist}}
77<ref name="kartoglu2014">Kartoglu U, Milstien J. "Tools and approaches to ensure quality of vaccines throughout the cold chain." ''Expert Review of Vaccines'' 13(7):843–854 (2014).</ref>79<ref name="kartoglu2014">Kartoglu U, Milstien J. "Tools and approaches to ensure quality of vaccines throughout the cold chain." ''Expert Review of Vaccines'' 13(7):843–854 (2014).</ref>
78<ref name="lloyd2017">Lloyd J, Cheyne J. "The origins of the vaccine cold chain and a glimpse of the future." ''Vaccine'' 35(17):2115–2120 (2017).</ref>80<ref name="lloyd2017">Lloyd J, Cheyne J. "The origins of the vaccine cold chain and a glimpse of the future." ''Vaccine'' 35(17):2115–2120 (2017).</ref>
+81<ref name="eugdp2013">European Commission. ''Guidelines of 5 November 2013 on Good Distribution Practice of medicinal products for human use'' (2013/C 343/01). Official Journal of the European Union.</ref>
79<ref name="ich_q1a">International Council for Harmonisation, ''Q1A(R2): Stability Testing of New Drug Substances and Products'' (2003).</ref>82<ref name="ich_q1a">International Council for Harmonisation, ''Q1A(R2): Stability Testing of New Drug Substances and Products'' (2003).</ref>
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