Weight regain after discontinuation (revision 1)
Old revision·09:10, 5 Sep 2024·StopperingSteff
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| Weight regain after discontinuation | |
|---|---|
| Evidence design | Randomised withdrawal after a lead-in |
| Principal trials | STEP 4, SURMOUNT-4 |
| Observed pattern | Steady regain towards baseline |
| Topic infobox · conventions | |
Weight regain after discontinuation is the return of body weight towards its pre-treatment value when incretin therapy stops. It has been documented in randomised withdrawal trials, which are the design capable of distinguishing it from the natural course of weight in a treated population.[1]
In STEP 4, participants who had reached the maintenance dose during a 20-week run-in were randomised to continue or to switch to placebo. Those continuing lost further weight; those switched regained steadily over the following 48 weeks.[1]