Underfilling: difference between revisions
Diff·revision 4 → 5·16:43, 15 Dec 2024
Difference between revision 4 and revision 5 of Underfilling. 3 lines changed; the page grew by 406 bytes.
| Revision 4 — 02:43, 2 Dec 2024 ReportReaderRilla (talk) add the note that self-submitted reports are a self-selected sample 1,727 bytes ±0 | Revision 5 — 16:43, 15 Dec 2024 ArchiveBot (talk) bot: add maintenance category 2,133 bytes +406 | ||
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| 10 | The quantity a purchaser cares about is the mass of peptide in the vial. That is the product of three things — the fill mass, the [[Peptide content|peptide content]] of the solid, and the purity — and a certificate reporting only the last of these constrains it hardly at all.{{r|usp1503}} | 10 | The quantity a purchaser cares about is the mass of peptide in the vial. That is the product of three things — the fill mass, the [[Peptide content|peptide content]] of the solid, and the purity — and a certificate reporting only the last of these constrains it hardly at all.{{r|usp1503}} |
| 11 | 11 | ||
| + | 12 | Underfilling has been documented in independently examined research-chemical material. It is also the failure most easily checked without a laboratory, since it requires only a balance of adequate resolution and an empty vial of the same type for tare.{{r|reports}} | |
| + | 13 | ||
| 12 | == Why purity does not detect it == | 14 | == Why purity does not detect it == |
| 13 | Chromatographic purity is computed as the area of the main peak divided by the total integrated area, expressed as a percentage. Both terms scale with the amount injected, so the ratio is invariant to concentration over the linear range of the detector.{{r|usp621}} | 15 | Chromatographic purity is computed as the area of the main peak divided by the total integrated area, expressed as a percentage. Both terms scale with the amount injected, so the ratio is invariant to concentration over the linear range of the detector.{{r|usp621}} |
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| 19 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | 21 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> |
| 20 | <ref name="usp621">United States Pharmacopeia, General Chapter <621>, ''Chromatography''.</ref> | 22 | <ref name="usp621">United States Pharmacopeia, General Chapter <621>, ''Chromatography''.</ref> |
| + | 23 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> | |
| 21 | 24 | ||
| 22 | {{DEFAULTSORT:Underfilling}} | 25 | {{DEFAULTSORT:Underfilling}} |