Trial data comparison: difference between revisions
Diff·revision 21 → 22·07:35, 15 Mar 2025
Difference between revision 21 and revision 22 of Trial data comparison. 3 lines changed; the page grew by 339 bytes.
| Revision 21 — 12:40, 9 Mar 2025 BalanceBirdie (talk) expand §Why the estimand matters 2,835 bytes ±0 | Revision 22 — 07:35, 15 Mar 2025 ExternalLinksEli (talk) copyedit 3,174 bytes +339 | ||
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| 10 | | Populations = Differ substantially between trials | 10 | | Populations = Differ substantially between trials |
| 11 | }} | 11 | }} |
| + | 12 | {{hatnote|For the programmes themselves, see [[STEP trial programme]], [[SURMOUNT trial programme]], [[SURPASS trial programme]] and [[TRIUMPH trial programme]].}} | |
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| 13 | The '''trial data comparison''' tabulates the principal published results of the major randomised trials of [[GLP-1 receptor agonist|GLP-1 receptor agonists]] and related compounds, so that a reader arriving at one figure can see the others alongside it. Each row is attributed to its trial, arm, duration and comparator. | 14 | The '''trial data comparison''' tabulates the principal published results of the major randomised trials of [[GLP-1 receptor agonist|GLP-1 receptor agonists]] and related compounds, so that a reader arriving at one figure can see the others alongside it. Each row is attributed to its trial, arm, duration and comparator. |
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| 27 | The '''treatment-policy estimand''' asks what happened to everyone randomised, including those who stopped the drug and those who started another one. It answers "what does prescribing this achieve", and it is the more conservative figure. | 28 | The '''treatment-policy estimand''' asks what happened to everyone randomised, including those who stopped the drug and those who started another one. It answers "what does prescribing this achieve", and it is the more conservative figure. |
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| + | 30 | The '''trial-product estimand''' asks what happened while participants were taking the drug as intended. It answers "what does the molecule do", and it is the larger figure. | |
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| 29 | == References == | 32 | == References == |