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Talk:Solid-phase peptide synthesis / Archive 1

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Intermediates cannot be purifiedResolved

That single constraint explains almost everything downstream — why crude purity matters, why preparative chromatography is the expensive step, why deletion sequences are the characteristic impurity. Good that it is in the lead. — SPPS_Sorrel (talk) 09:30, 18 January 2026 (UTC)

It is the trade-off Merrifield accepted in exchange for washing, and stating it as a trade-off rather than a flaw is the right framing. ✓ Done — ResinRhoswen (talk) 13:05, 18 January 2026 (UTC)

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