Subcutaneous injection: difference between revisions
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| 21 | Volume is limited by the compliance of the tissue. More than about 1.5 mL at one site produces discomfort and a visible bleb, and larger volumes are split. Peptide doses in this field are usually well under that, since a few milligrams of peptide occupy a very small volume at ordinary reconstitution concentrations.{{r|richter2012,usp1503}} | 21 | Volume is limited by the compliance of the tissue. More than about 1.5 mL at one site produces discomfort and a visible bleb, and larger volumes are split. Peptide doses in this field are usually well under that, since a few milligrams of peptide occupy a very small volume at ordinary reconstitution concentrations.{{r|richter2012,usp1503}} |
| 22 | 22 | ||
| + | 23 | == Site differences == | |
| + | 24 | | Site | Relative absorption rate | Notes | | |
| + | 25 | |---|---|---| | |
| + | 26 | | Abdomen | Fastest | Avoiding the immediate periumbilical area is conventional | | |
| + | 27 | | Upper arm | Intermediate | Subcutaneous layer may be thin | | |
| + | 28 | | Thigh | Slower | Exercise increases local flow | | |
| + | 29 | | Buttock | Slowest | Consistent, less affected by activity | | |
| + | 30 | ||
| + | 31 | Differences of this kind are established for insulin and are commonly extrapolated to other subcutaneous preparations. The extrapolation is reasonable but is an extrapolation: for a peptide whose absorption half-life is long relative to its elimination half-life, site differences are absorbed into the profile and become clinically undetectable.{{r|richter2012}} | |
| + | 32 | ||
| 23 | == References == | 33 | == References == |
| 24 | {{reflist}} | 34 | {{reflist}} |