Sterile water for injection: difference between revisions
Diff·revision 11 → 12·09:18, 26 Jan 2025
Difference between revision 11 and revision 12 of Sterile water for injection. 3 lines changed; the page grew by 390 bytes.
| Revision 11 — 00:09, 7 Jan 2025 Chromatokid (talk) state that reconstituted material should not be frozen, with the source 3,229 bytes +143 | Revision 12 — 09:18, 26 Jan 2025 RotationRosalind (talk) fix the arithmetic in the worked reconstitution example 3,619 bytes +390 | ||
|---|---|---|---|
| 25 | The trade-off is direct. An unpreserved container must be treated as single-entry, so any material remaining is discarded; a preserved container can be entered repeatedly within its dating. Where a small quantity of active substance is reconstituted into a volume larger than a single withdrawal, that difference determines how much of the material is usable. | 25 | The trade-off is direct. An unpreserved container must be treated as single-entry, so any material remaining is discarded; a preserved container can be entered repeatedly within its dating. Where a small quantity of active substance is reconstituted into a volume larger than a single withdrawal, that difference determines how much of the material is usable. |
| 26 | 26 | ||
| + | 27 | For research peptides, compatibility with benzyl alcohol is generally uncharacterised, so neither choice can be justified on compatibility grounds from published data. That is a statement about the evidence rather than a recommendation.{{r|usp1503}} | |
| + | 28 | ||
| 27 | == References == | 29 | == References == |
| 28 | {{reflist}} | 30 | {{reflist}} |
| ⋮ | ⋮ | ||
| 30 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, ''Pharmaceutical Compounding — Sterile Preparations''.</ref> | 32 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, ''Pharmaceutical Compounding — Sterile Preparations''.</ref> |
| 31 | <ref name="usp85">United States Pharmacopeia, General Chapter <85>, ''Bacterial Endotoxins Test''.</ref> | 33 | <ref name="usp85">United States Pharmacopeia, General Chapter <85>, ''Bacterial Endotoxins Test''.</ref> |
| + | 34 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | |
| 32 | 35 | ||
| 33 | == See also == | 36 | == See also == |