Satiety signalling (revision 1)
Old revision·09:00, 14 Aug 2024·BetaCellBoyd
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| Satiety signalling | |
|---|---|
| Satiation | Termination of a meal in progress |
| Satiety | Suppression of intake between meals |
| Principal relay | Nucleus of the solitary tract, area postrema |
| Topic infobox · conventions | |
Satiety signalling comprises the peripheral signals and central circuits that end a meal and delay the next one. The literature distinguishes satiation — the process terminating an eating episode — from satiety, the inter-meal suppression of appetite; the distinction matters because different signals dominate each.[1]
Peripheral signals include gastric distension relayed by vagal mechanoreceptors, nutrient-sensing hormones from the small intestine such as cholecystokinin, GLP-1, peptide YY and amylin, and longer-term adiposity signals such as leptin and insulin. These converge on the caudal brainstem and on hypothalamic circuits including the arcuate nucleus.[1]
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