Satiety signalling: difference between revisions
Diff·revision 2 → 3·02:53, 2 Sep 2024
Difference between revision 2 and revision 3 of Satiety signalling. 6 lines changed; the page grew by 844 bytes.
| Revision 2 — 22:03, 18 Aug 2024 AmylinAmos (talk) add category for receptor pharmacology 1,326 bytes ±0 | Revision 3 — 02:53, 2 Sep 2024 BetaCellBoyd (talk) move a stray full stop inside the reference 2,170 bytes +844 | ||
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| 10 | Peripheral signals include gastric distension relayed by vagal mechanoreceptors, nutrient-sensing hormones from the small intestine such as cholecystokinin, [[Glucagon-like peptide-1|GLP-1]], peptide YY and [[Amylin|amylin]], and longer-term adiposity signals such as leptin and insulin. These converge on the caudal brainstem and on hypothalamic circuits including the [[Arcuate nucleus|arcuate nucleus]].{{r|woods2009}} | 10 | Peripheral signals include gastric distension relayed by vagal mechanoreceptors, nutrient-sensing hormones from the small intestine such as cholecystokinin, [[Glucagon-like peptide-1|GLP-1]], peptide YY and [[Amylin|amylin]], and longer-term adiposity signals such as leptin and insulin. These converge on the caudal brainstem and on hypothalamic circuits including the [[Arcuate nucleus|arcuate nucleus]].{{r|woods2009}} |
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| + | 12 | == Peripheral signals == | |
| + | 13 | Gastric distension is the most immediate satiation signal, relayed by vagal afferents in the stomach wall. It is volume-dependent rather than calorie-dependent, which is why delayed [[Gastric emptying|gastric emptying]] produces satiation out of proportion to the nutrient consumed.{{r|woods2009}} | |
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| + | 15 | Intestinal hormones add nutrient specificity. Cholecystokinin is released from duodenal I cells in response to fat and protein and acts largely within a meal. GLP-1 and peptide YY are released from more distal [[Enteroendocrine L cell|L cells]] and act over a longer window. Amylin, co-secreted with insulin from the pancreas, acts at the area postrema.{{r|holst2007}} | |
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| 12 | == References == | 17 | == References == |
| 13 | {{reflist}} | 18 | {{reflist}} |
| 14 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). DOI:10.1016/j.cmet.2009.04.007. PMID 19490904.</ref> | 19 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). DOI:10.1016/j.cmet.2009.04.007. PMID 19490904.</ref> |
| + | 20 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> | |
| 15 | 21 | ||
| 16 | {{DEFAULTSORT:Satiety signalling}} | 22 | {{DEFAULTSORT:Satiety signalling}} |