Sarcopenia: difference between revisions
Diff·revision 17 → 18·05:24, 20 Aug 2025
Difference between revision 17 and revision 18 of Sarcopenia. 5 lines changed; the page grew by 477 bytes.
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| 33 | Resistance exercise and adequate protein intake are the interventions with evidence for attenuating lean-mass loss during caloric restriction generally. Extrapolating that evidence to pharmacological weight loss is reasonable and is an extrapolation.{{r|cruzjentoft2019}} | 33 | Resistance exercise and adequate protein intake are the interventions with evidence for attenuating lean-mass loss during caloric restriction generally. Extrapolating that evidence to pharmacological weight loss is reasonable and is an extrapolation.{{r|cruzjentoft2019}} |
| 34 | 34 | ||
| + | 35 | == What would settle the question == | |
| + | 36 | A trial randomising to pharmacological or dietary weight loss matched for total weight change, with functional endpoints rather than composition alone, and adequate duration and power. No such trial has reported.{{r|wilding2021}} | |
| + | 37 | ||
| + | 38 | Until one does, the honest position is that lean-mass loss is documented, its functional consequence is not, and the difference between the two is the difference between a measurement and a clinical outcome. | |
| + | 39 | ||
| 35 | == References == | 40 | == References == |
| 36 | {{reflist}} | 41 | {{reflist}} |