SURMOUNT trial programme: difference between revisions
Diff·revision 10 → 11·11:36, 14 Dec 2024
Difference between revision 10 and revision 11 of SURMOUNT trial programme. 5 lines changed; the page grew by 435 bytes.
| Revision 10 — 18:06, 26 Nov 2024 PatientPanelPru (talk) give the absolute risk difference alongside the relative one 2,702 bytes +34 | Revision 11 — 11:36, 14 Dec 2024 SurpassSunniva (talk) add the missing-data handling method 3,137 bytes +435 | ||
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| 27 | SURMOUNT-3 shows that a lifestyle lead-in does not exhaust the available effect: participants who had already lost weight on intensive lifestyle intervention lost further weight on active treatment.{{r|jastreboff2022}} | 27 | SURMOUNT-3 shows that a lifestyle lead-in does not exhaust the available effect: participants who had already lost weight on intensive lifestyle intervention lost further weight on active treatment.{{r|jastreboff2022}} |
| 28 | 28 | ||
| + | 29 | == Reading the figures == | |
| + | 30 | The 72-week duration includes a 20-week escalation, so as in [[STEP trial programme|STEP]] a substantial part of the trial was spent below the maintenance dose.{{r|jastreboff2022}} | |
| + | 31 | ||
| + | 32 | Weight-change curves at the higher doses were still declining at 72 weeks rather than plateauing, which limits what the endpoint figure says about the eventual effect and is one reason the programme's later trials run longer. | |
| + | 33 | ||
| 29 | == References == | 34 | == References == |
| 30 | {{reflist}} | 35 | {{reflist}} |