SELECT trial (revision 4)
Old revision·15:04, 8 Sep 2024·ConsensusConal
| SELECT trial | |
|---|---|
| Drug | Semaglutide 2.4 mg weekly |
| Population | Established CVD, BMI ≥27, no diabetes |
| Participants | 17,604 |
| Primary result | MACE HR 0.80 (95% CI 0.72–0.90) |
| Topic infobox · conventions | |
SELECT was a randomised, double-blind, placebo-controlled cardiovascular outcome trial of weekly semaglutide 2.4 mg in 17,604 adults with established cardiovascular disease and a body-mass index of 27 or above, and without diabetes.[1]
The primary composite outcome — cardiovascular death, non-fatal myocardial infarction or non-fatal stroke — occurred in 6.5% of the semaglutide group and 8.0% of the placebo group over a mean follow-up of 39.8 months, a hazard ratio of 0.80 (95% CI 0.72–0.90).[1]
Design
[edit]Participants were 45 or older with established cardiovascular disease — prior myocardial infarction, prior stroke, or symptomatic peripheral arterial disease — and overweight or obesity, and were excluded if they had diabetes. Both groups continued standard cardiovascular care.[1]
This is an important design feature: the trial tested semaglutide added to background therapy including statins and antiplatelet agents in a majority of participants, so the observed effect is incremental to contemporary secondary prevention rather than a comparison against nothing.