Reference standard: difference between revisions
Diff·revision 15 → 16·16:57, 1 Feb 2025
Difference between revision 15 and revision 16 of Reference standard. 2 lines changed; the page grew by 353 bytes.
| Revision 15 — 09:25, 12 Jan 2025 Chromatokid (talk) convert a hard-coded date to the house format 3,767 bytes ±0 | Revision 16 — 16:57, 1 Feb 2025 TechnicianTeal (talk) add category for method validation 4,120 bytes +353 | ||
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| 25 | Co-injection strengthens it. Spiking the sample with the standard should increase the area of the existing peak without producing a shoulder or a second peak; a shoulder indicates the two are not the same species. This is a simple and informative experiment that is rarely reported on research-chemical certificates. | 25 | Co-injection strengthens it. Spiking the sample with the standard should increase the area of the existing peak without producing a shoulder or a second peak; a shoulder indicates the two are not the same species. This is a simple and informative experiment that is rarely reported on research-chemical certificates. |
| 26 | 26 | ||
| + | 27 | Identification is stronger still when retention matching is combined with an orthogonal determination — [[Mass spectrometry|mass confirmation]], or a second chromatographic mode with different selectivity. The combination is what pharmacopoeial identification tests specify, and it is a reasonable benchmark for reading any certificate.{{r|usp1503}} | |
| + | 28 | ||
| 27 | == References == | 29 | == References == |
| 28 | {{reflist}} | 30 | {{reflist}} |