Reconstitution of lyophilised peptides: difference between revisions
Diff·revision 24 → 25·10:16, 18 Jul 2025
Difference between revision 24 and revision 25 of Reconstitution of lyophilised peptides. 2 lines changed; the page grew by 518 bytes.
| Revision 24 — 09:26, 28 Jun 2025 SubQ_Solveig (talk) rm a duplicated category 5,243 bytes ±0 | Revision 25 — 10:16, 18 Jul 2025 OrphanPageOrin (talk) copyedit 5,761 bytes +518 | ||
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| 42 | Refrigeration slows chemical degradation substantially: rate constants for deamidation and oxidation fall several-fold between ambient and 2–8 °C. Freezing a reconstituted peptide solution is generally counterproductive, since ice formation concentrates solutes and creates interfaces, and repeated freeze–thaw is a well-documented cause of aggregation.{{r|manning2010}} | 42 | Refrigeration slows chemical degradation substantially: rate constants for deamidation and oxidation fall several-fold between ambient and 2–8 °C. Freezing a reconstituted peptide solution is generally counterproductive, since ice formation concentrates solutes and creates interfaces, and repeated freeze–thaw is a well-documented cause of aggregation.{{r|manning2010}} |
| 43 | 43 | ||
| + | 44 | Where a preservative is absent, the limiting factor is microbiological rather than chemical, and it applies from the first entry of the container. Research-chemical powders are not sterile products — see [[Sterility testing]] — so a reconstituted solution is not a sterile solution regardless of diluent. Nothing here is medical advice, and research-use compounds are not approved for human administration; see [[Beyond-use date]] for how dating is assigned in settings where it is formally required.{{r|usp797}} | |
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| 44 | == References == | 46 | == References == |
| 45 | {{reflist}} | 47 | {{reflist}} |