Placebo-adjusted effect: difference between revisions

Diff·revision 14 → 15·13:30, 17 Jun 2025

Difference between revision 14 and revision 15 of Placebo-adjusted effect. 6 lines changed; the page grew by 688 bytes.

Revision 14 — 12:51, 20 May 2025 ParentCatPansy (talk) expand §How figures are misreported 3,893 bytes ±0	Revision 15 — 13:30, 17 Jun 2025 LeaderLoic (talk) give the absolute risk difference alongside the relative one 4,581 bytes +688
32	Cross-trial comparison compounds all of this. Two trials with different lifestyle interventions have different placebo arms, so their active-arm figures are not comparable even when the drug effects are.{{r\|wilding2021}}	32	Cross-trial comparison compounds all of this. Two trials with different lifestyle interventions have different placebo arms, so their active-arm figures are not comparable even when the drug effects are.{{r\|wilding2021}}
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+		34	== Where the adjustment is not enough ==
+		35	Placebo adjustment removes what the comparator arm experienced. It does not remove differences in population, in duration, in escalation schedule, or in analysis approach — which is why a placebo-adjusted figure from one trial is still not directly comparable with one from another.{{r\|ich_e9}}
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+		37	Nor does it address blinding failure. An agent producing marked gastrointestinal effects is not perfectly blinded in practice, and participants who infer their allocation may behave differently. This is unquantifiable and is a general limitation of trials of agents with distinctive effects.{{r\|hrobjartsson2010}}
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34	== References ==	39	== References ==
35	{{reflist}}	40	{{reflist}}
⋮		⋮
44	* [[STEP trial programme]]	49	* [[STEP trial programme]]
45	* [[SURMOUNT trial programme]]	50	* [[SURMOUNT trial programme]]
+		51	* [[Randomised controlled trial]]
46		52
47	{{DEFAULTSORT:Placebo-adjusted effect}}	53	{{DEFAULTSORT:Placebo-adjusted effect}}