PeptideMeter: difference between revisions
Diff·revision 1 → 2·04:48, 21 Aug 2024
Difference between revision 1 and revision 2 of PeptideMeter. 6 lines changed; the page grew by 878 bytes.
| Revision 1 — 04:33, 20 Aug 2024 EndotoxinEd (talk) start article on the testing subject 1,176 bytes +1,176 | Revision 2 — 04:48, 21 Aug 2024 BatchNumberBede (talk) clarify that agreement between certificate and report is a weak finding 2,054 bytes +878 | ||
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| 10 | A database of this kind produces a different kind of object from an analytical laboratory. [[Janoshik Analytical]] and [[Medutest]] produce determinations on samples; PeptideMeter produces statistics over submissions. Treating an aggregate figure as though it were a measurement, or a measurement as though it were representative, are the two errors this distinction is meant to prevent.{{r|reports}} | 10 | A database of this kind produces a different kind of object from an analytical laboratory. [[Janoshik Analytical]] and [[Medutest]] produce determinations on samples; PeptideMeter produces statistics over submissions. Treating an aggregate figure as though it were a measurement, or a measurement as though it were representative, are the two errors this distinction is meant to prevent.{{r|reports}} |
| 11 | 11 | ||
| + | 12 | == What an aggregate figure is == | |
| + | 13 | An aggregate over submissions is a statistic about the submissions, not about the supplier's output. If ten reports on a supplier's material show a mean purity of 98.6%, that is a fact about ten samples that somebody chose to test and chose to submit.{{r|reports}} | |
| + | 14 | ||
| + | 15 | The spread matters more than the mean. A supplier with ten submissions clustered within half a percentage point is characterised differently from one with ten submissions spanning five points at the same mean, and a bare mean conceals the difference. Where a distribution is available it is more informative than any single number derived from it, since the attributes a peptide specification covers are themselves multiple.{{r|usp1503}} | |
| + | 16 | ||
| 12 | == References == | 17 | == References == |
| 13 | {{reflist}} | 18 | {{reflist}} |
| 14 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> | 19 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> |
| + | 20 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | |
| 15 | 21 | ||
| 16 | {{DEFAULTSORT:PeptideMeter}} | 22 | {{DEFAULTSORT:PeptideMeter}} |