Multi-dose vial: difference between revisions
Diff·revision 21 → 22·15:17, 6 May 2025
Difference between revision 21 and revision 22 of Multi-dose vial. 3 lines changed; the page grew by 341 bytes.
| Revision 21 — 02:07, 30 Apr 2025 FiveOhThreeB (talk) fix unit 12,489 bytes ±0 | Revision 22 — 15:17, 6 May 2025 GramsNotUnitsGil (talk) cite the trial publication rather than the press release 12,830 bytes +341 | ||
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| 1 | {{Infobox concept | 1 | {{Infobox concept |
| 2 | | name = Multi-dose vial | 2 | | name = Multi-dose vial |
| + | 3 | | subtitle = Multiple-dose container | |
| 3 | | image = vial.svg | 4 | | image = vial.svg |
| 4 | | caption = Repeated penetration of a single closure is the defining feature, and the source of both the preservative requirement and the coring risk. | 5 | | caption = Repeated penetration of a single closure is the defining feature, and the source of both the preservative requirement and the coring risk. |
| ⋮ | ⋮ | ||
| 55 | 56 | ||
| 56 | Conversely, benzyl alcohol has been reported to destabilise some proteins, promoting aggregation at concentrations within the preservative range. The interaction is protein-specific, and reports concern proteins rather than short synthetic peptides, for which the equivalent question appears not to have been systematically addressed.{{r|manning2010mdv}} | 57 | Conversely, benzyl alcohol has been reported to destabilise some proteins, promoting aggregation at concentrations within the preservative range. The interaction is protein-specific, and reports concern proteins rather than short synthetic peptides, for which the equivalent question appears not to have been systematically addressed.{{r|manning2010mdv}} |
| + | 58 | ||
| + | 59 | {{note|A preservative suppresses growth of organisms introduced during use. It does not sterilise a contaminated preparation, does not act instantaneously, and is ineffective against blood-borne viruses. Contamination of a vial with blood via a reused syringe is not addressed by any preservative.}} | |
| 57 | 60 | ||
| 58 | === Preservative loss during use === | 61 | === Preservative loss during use === |