MOTS-c: difference between revisions
Diff·revision 13 → 14·21:31, 17 May 2025
Difference between revision 13 and revision 14 of MOTS-c. 3 lines changed; the page grew by 256 bytes.
| Revision 13 — 22:48, 2 May 2025 MissedDoseMik (talk) state which receptor subtype the binding data refers to 3,340 bytes +30 | Revision 14 — 21:31, 17 May 2025 MOTSc_Mira (talk) clarify that the compound is sold as an acetate salt 3,596 bytes +256 | ||
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| 7 | | Status = Not approved; preclinical and early human study | 7 | | Status = Not approved; preclinical and early human study |
| 8 | }} | 8 | }} |
| + | 9 | {{medical|talk=Unapproved-compound notice}} | |
| 9 | 10 | ||
| 10 | '''MOTS-c''' is a 16-residue peptide encoded within the mitochondrial genome rather than the nuclear genome, and is one of a small group of mitochondria-derived peptides identified since the 2000s. It is not approved for any indication.{{r|lee2015}} | 11 | '''MOTS-c''' is a 16-residue peptide encoded within the mitochondrial genome rather than the nuclear genome, and is one of a small group of mitochondria-derived peptides identified since the 2000s. It is not approved for any indication.{{r|lee2015}} |
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| 25 | 26 | ||
| 26 | In humans, exercise increases circulating MOTS-c, and lower concentrations have been associated with obesity and insulin resistance in cross-sectional studies. Association of that kind cannot establish direction: lower concentrations may contribute to the phenotype or result from it.{{r|kim2018}} | 27 | In humans, exercise increases circulating MOTS-c, and lower concentrations have been associated with obesity and insulin resistance in cross-sectional studies. Association of that kind cannot establish direction: lower concentrations may contribute to the phenotype or result from it.{{r|kim2018}} |
| + | 28 | ||
| + | 29 | No adequately powered controlled trial of administration in humans has reported. The gap between the preclinical literature and the human evidence is wide, and it should not be closed by inference.{{r|lee2015}} | |
| 27 | 30 | ||
| 28 | == References == | 31 | == References == |