Lyophilisation: difference between revisions
Diff·revision 8 → 9·18:33, 23 Sep 2024
Difference between revision 8 and revision 9 of Lyophilisation. 3 lines changed; the page grew by 607 bytes.
| Revision 8 — 18:30, 17 Sep 2024 Chromatokid (talk) undo good-faith edit: the source does not say this 4,024 bytes ±0 | Revision 9 — 18:33, 23 Sep 2024 LipidLedgerLou (talk) fix category — parent was wrong 4,631 bytes +607 | ||
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| 28 | | −50 °C | 3.94 Pa | 0.0064 | | 28 | | −50 °C | 3.94 Pa | 0.0064 | |
| 29 | 29 | ||
| + | 30 | Values follow the standard formulations reviewed by Murphy and Koop.{{r|murphy2005}} The table explains a practical asymmetry of the process: a cycle run with the product at −40 °C rather than −30 °C loses roughly two-thirds of its driving force, and a cycle run 5 °C warmer than intended may dry substantially faster while risking the structural failure described below. | |
| + | 31 | ||
| 30 | == References == | 32 | == References == |
| 31 | {{reflist}} | 33 | {{reflist}} |
| ⋮ | ⋮ | ||
| 35 | <ref name="carpenter1997">Carpenter JF, Pikal MJ, Chang BS, Randolph TW. "Rational design of stable lyophilized protein formulations: some practical advice." ''Pharmaceutical Research'' 14(8):969–975 (1997).</ref> | 37 | <ref name="carpenter1997">Carpenter JF, Pikal MJ, Chang BS, Randolph TW. "Rational design of stable lyophilized protein formulations: some practical advice." ''Pharmaceutical Research'' 14(8):969–975 (1997).</ref> |
| 36 | <ref name="chang2009">Chang LL, Pikal MJ. "Mechanisms of protein stabilization in the solid state." ''Journal of Pharmaceutical Sciences'' 98(9):2886–2908 (2009).</ref> | 38 | <ref name="chang2009">Chang LL, Pikal MJ. "Mechanisms of protein stabilization in the solid state." ''Journal of Pharmaceutical Sciences'' 98(9):2886–2908 (2009).</ref> |
| + | 39 | <ref name="murphy2005">Murphy DM, Koop T. "Review of the vapour pressures of ice and supercooled water for atmospheric applications." ''Quarterly Journal of the Royal Meteorological Society'' 131(608):1539–1565 (2005).</ref> | |
| 37 | 40 | ||
| 38 | {{DEFAULTSORT:Lyophilisation}} | 41 | {{DEFAULTSORT:Lyophilisation}} |