Lyophilisation: difference between revisions
Diff·revision 48 → 49·08:12, 1 Jul 2025
Difference between revision 48 and revision 49 of Lyophilisation. 2 lines changed; the page grew by 284 bytes.
| Revision 48 — 05:22, 23 Jun 2025 BacWaterBarnaby (talk) add short description 23,183 bytes +568 | Revision 49 — 08:12, 1 Jul 2025 CiteBot (talk) bot: flag bare reference 23,467 bytes +284 | ||
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| 142 | Residual moisture is measured by [[Karl Fischer titration]] or, less specifically, by [[Loss on drying|loss on drying]]. A discrepancy between the two on the same lot is informative: loss on drying substantially exceeding the Karl Fischer figure suggests [[Residual solvent|residual solvent]], whereas the reverse suggests water bound too tightly to be driven off at the drying temperature. | 142 | Residual moisture is measured by [[Karl Fischer titration]] or, less specifically, by [[Loss on drying|loss on drying]]. A discrepancy between the two on the same lot is informative: loss on drying substantially exceeding the Karl Fischer figure suggests [[Residual solvent|residual solvent]], whereas the reverse suggests water bound too tightly to be driven off at the drying temperature. |
| 143 | 143 | ||
| + | 144 | Reconstitution time and clarity detect collapse, over-concentration and incipient aggregation. A cake that requires prolonged agitation, or that yields a hazy solution, is a documented indicator of physical instability even when chemical assay is within specification.{{r|wang2000}} | |
| + | 145 | ||
| 144 | == References == | 146 | == References == |
| 145 | {{reflist}} | 147 | {{reflist}} |