Karl Fischer titration: difference between revisions
Diff·revision 35 → 36·14:47, 12 Feb 2025
Difference between revision 35 and revision 36 of Karl Fischer titration. 2 lines changed; the page grew by 538 bytes.
| Revision 35 — 09:03, 3 Feb 2025 SigFigSindri (talk) attribute range as a review estimate per talk 6,021 bytes ±0 | Revision 36 — 14:47, 12 Feb 2025 AnalyticalAnnie (talk) copyedit 6,559 bytes +538 | ||
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| 61 | * '''Strongly bound water''' may not be released at cell temperature; an oven accessory that thermally desorbs water into the cell under dry carrier gas addresses this and is the usual arrangement for peptides with tightly bound hydration. | 61 | * '''Strongly bound water''' may not be released at cell temperature; an oven accessory that thermally desorbs water into the cell under dry carrier gas addresses this and is the usual arrangement for peptides with tightly bound hydration. |
| 62 | 62 | ||
| + | 63 | Peptides containing free cysteine are the interference most relevant here, since a thiol-bearing sequence can give a falsely elevated water figure.{{cn}} A discrepancy between Karl Fischer and [[Loss on drying|loss-on-drying]] results on the same lot is a useful diagnostic: loss on drying measures all volatiles, so LOD substantially exceeding KF suggests [[Residual solvent|residual solvent]], whereas KF exceeding LOD suggests either an interference or water too tightly bound to be driven off at the drying temperature.{{r|usp1503}} | |
| + | 64 | ||
| 63 | == References == | 65 | == References == |
| 64 | {{reflist}} | 66 | {{reflist}} |