International nonproprietary name: difference between revisions
Diff·revision 15 → 16·19:22, 7 Jun 2025
Difference between revision 15 and revision 16 of International nonproprietary name. 7 lines changed; the page grew by 817 bytes.
| Revision 15 — 09:21, 16 May 2025 MazdutideMads (talk) fix the amino-acid substitution — position 8, not position 2 3,183 bytes ±0 | Revision 16 — 19:22, 7 Jun 2025 DulaglutideDug (talk) state the substitution in one-letter code as well, per PP:MOS 4,000 bytes +817 | ||
|---|---|---|---|
| 35 | Development codes — LY3437943, BI 456906 — precede the INN and appear in the early literature. A compound may be discussed under a code, then an INN, then a trade name, and secondary sources do not always connect them. See [[Retatrutide]] and [[Survodutide]].{{r|who_inn}} | 35 | Development codes — LY3437943, BI 456906 — precede the INN and appear in the early literature. A compound may be discussed under a code, then an INN, then a trade name, and secondary sources do not always connect them. See [[Retatrutide]] and [[Survodutide]].{{r|who_inn}} |
| 36 | 36 | ||
| + | 37 | == Practical use == | |
| + | 38 | For a reader trying to establish what a substance is, the INN is the most reliable identifier: it is unique, it is stable, and its stem places the compound in a class.{{r|who_inn}} | |
| + | 39 | ||
| + | 40 | For material sold outside licensed supply, a name on a label is an assertion like any other field. A vial labelled with an INN has been labelled; whether its contents correspond is an identity question answered by [[Mass spectrometry|mass determination]], not by the label.{{r|usp1503,aebersold2003}} See [[Counterfeit peptide]]. | |
| + | 41 | ||
| 37 | == References == | 42 | == References == |
| 38 | {{reflist}} | 43 | {{reflist}} |
| 39 | <ref name="who_inn">World Health Organization, ''Guidance on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances'' and the published INN stem list.</ref> | 44 | <ref name="who_inn">World Health Organization, ''Guidance on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances'' and the published INN stem list.</ref> |
| + | 45 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | |
| + | 46 | <ref name="aebersold2003">Aebersold R, Mann M. "Mass spectrometry-based proteomics." ''Nature'' 422(6928):198–207 (2003). PMID 12634793.</ref> | |
| 40 | 47 | ||
| 41 | == See also == | 48 | == See also == |