Haemoglobin A1c: difference between revisions
Diff·revision 8 → 9·11:58, 18 Dec 2024
Difference between revision 8 and revision 9 of Haemoglobin A1c. 17 lines changed; the page grew by 608 bytes.
| Revision 8 — 19:41, 19 Nov 2024 DrTitration (talk) de-orphan 2,610 bytes +36 | Revision 9 — 11:58, 18 Dec 2024 Peptide_Pete (talk) expand §Confounders 3,218 bytes +608 | ||
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| 21 | Estimated average glucose can be derived from HbA1c by a published regression, and the derivation carries substantial individual variation — two people with identical HbA1c can have appreciably different mean glucose.{{r|nathan2008}} The measure is a laboratory determination with its own method dependence, as any determination is.{{r|usp1503}} | 21 | Estimated average glucose can be derived from HbA1c by a published regression, and the derivation carries substantial individual variation — two people with identical HbA1c can have appreciably different mean glucose.{{r|nathan2008}} The measure is a laboratory determination with its own method dependence, as any determination is.{{r|usp1503}} |
| 22 | 22 | ||
| + | 23 | == Confounders == | |
| + | 24 | | Condition | Direction | | |
| + | 25 | |---|---| | |
| + | 26 | | Haemolysis, blood loss, transfusion | Lower | | |
| + | 27 | | Iron or B12 deficiency | Higher | | |
| + | 28 | | Chronic kidney disease | Variable | | |
| + | 29 | | Haemoglobin variants | Assay-dependent interference | | |
| + | 30 | | Pregnancy | Lower, from increased turnover | | |
| + | 31 | ||
| + | 32 | Haemoglobin variants interfere with some assay methods and not others, so a discrepancy between HbA1c and other glycaemic measures should prompt a question about the method rather than an assumption about glucose.{{r|ada2024}} | |
| + | 33 | ||
| 23 | == References == | 34 | == References == |
| 24 | {{reflist}} | 35 | {{reflist}} |
| ⋮ | ⋮ | ||
| 26 | <ref name="nathan2008">Nathan DM, Kuenen J, Borg R, et al. "Translating the A1C assay into estimated average glucose values." ''Diabetes Care'' 31(8):1473–1478 (2008). PMID 18540046.</ref> | 37 | <ref name="nathan2008">Nathan DM, Kuenen J, Borg R, et al. "Translating the A1C assay into estimated average glucose values." ''Diabetes Care'' 31(8):1473–1478 (2008). PMID 18540046.</ref> |
| 27 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | 38 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> |
| + | 39 | ||
| + | 40 | == See also == | |
| + | 41 | * [[Baseline laboratory panel]] | |
| + | 42 | * [[Fasting insulin]] | |
| + | 43 | * [[C-peptide]] | |
| + | 44 | * [[HOMA-IR]] | |
| 28 | 45 | ||
| 29 | {{DEFAULTSORT:Haemoglobin A1c}} | 46 | {{DEFAULTSORT:Haemoglobin A1c}} |