HOMA-IR (revision 4)
Old revision·06:54, 23 Oct 2024·Chromatokid
| HOMA-IR | |
|---|---|
| Full name | Homeostatic model assessment of insulin resistance |
| Inputs | Fasting glucose and fasting insulin |
| Reference method | Hyperinsulinaemic-euglycaemic clamp |
| Topic infobox · conventions | |
HOMA-IR is an index of insulin resistance derived from a single fasting sample. In its original linear approximation it is the product of fasting glucose and fasting insulin divided by a constant, and it correlates moderately with clamp-derived measures of insulin sensitivity across populations.[1]
Its appeal is that it requires one blood draw rather than a several-hour clamp. Its weakness is that it is a model-derived approximation from two values, inherits the poor standardisation of insulin assays, and describes hepatic rather than peripheral insulin resistance most directly.[2]
Calculation and the two forms
[edit]The original linear approximation is
\text{HOMA-IR} = (\text{glucose}\text{mmol/L} \times \text{insulin}\text{mU/L}) / 22.5
A revised non-linear computer model, HOMA2, was published later and gives different values, particularly at the extremes. The two are not interchangeable, and a figure quoted without saying which was used is ambiguous.[2]
References
- ^ Matthews DR, Hosker JP, Rudenski AS, et al. "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man." Diabetologia 28(7):412–419 (1985). PMID 3899825.
- ^ a b Wallace TM, Levy JC, Matthews DR. "Use and abuse of HOMA modeling." Diabetes Care 27(6):1487–1495 (2004). PMID 15161807.