Glucagon-like peptide-1 (revision 7)
Old revision·18:36, 29 Jun 2024·Retention_Time_Rae
This is an old revision of this page, as it stood at 18:36, 29 Jun 2024, saved by Retention_Time_Rae with the summary expand §Impaired incretin response in disease. It may differ substantially from the current revision, and any error it contains may since have been corrected.
| Glucagon-like peptide-1 | |
|---|---|
| Abbreviation | GLP-1 |
| Precursor | Proglucagon (gene GCG) |
| Principal source | Intestinal L cells |
| Topic infobox · conventions | |
Glucagon-like peptide-1 (GLP-1) is a 30- or 31-residue peptide hormone released from enteroendocrine L cells of the distal small intestine and colon in response to nutrient ingestion. It is one of the two principal incretin hormones, the other being Glucose-dependent insulinotropic polypeptide (GIP).[1]
GLP-1 is generated by tissue-specific post-translational processing of proglucagon, the same precursor that yields glucagon in pancreatic alpha cells. In the intestine, prohormone convertase 1/3 liberates GLP-1 (7–37) and its C-terminally amidated form GLP-1 (7–36) amide, the latter accounting for the majority of circulating immunoreactive GLP-1 in humans.[2]
References
- ^ Holst JJ. "The physiology of glucagon-like peptide 1." Physiological Reviews 87(4):1409–1439 (2007). DOI:10.1152/physrev.00034.2006. PMID 17928588.
- ^ Baggio LL, Drucker DJ. "Biology of incretins: GLP-1 and GIP." Gastroenterology 132(6):2131–2157 (2007). DOI:10.1053/j.gastro.2007.03.054. PMID 17498508.
Categories: