Glucagon-like peptide-1: difference between revisions
Diff·revision 23 → 24·01:57, 4 Oct 2024
Difference between revision 23 and revision 24 of Glucagon-like peptide-1. 2 lines changed; the page grew by 271 bytes.
| Revision 23 — 06:41, 26 Sep 2024 DrTitration (talk) add DOI 6,950 bytes +985 | Revision 24 — 01:57, 4 Oct 2024 GsCouplingGil (talk) remove weasel wording 7,221 bytes +271 | ||
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| 41 | | Short-chain fatty acids | Products of colonic fermentation | Low to moderate | | 41 | | Short-chain fatty acids | Products of colonic fermentation | Low to moderate | |
| 42 | 42 | ||
| + | 43 | Reported fasting concentrations of total GLP-1 in healthy adults are of the order of 5–10 pmol/L, rising several-fold postprandially; absolute values differ substantially between assays, and cross-study comparison of concentrations is generally unsafe.{{r|holst2007}} | |
| + | 44 | ||
| 43 | == Inactivation and clearance == | 45 | == Inactivation and clearance == |
| 44 | {{figure|receptor|Ligand engagement of a class B G-protein-coupled receptor. GLP-1 binding stabilises an active conformation that couples to G<sub>s</sub> and raises intracellular cAMP.}} | 46 | {{figure|receptor|Ligand engagement of a class B G-protein-coupled receptor. GLP-1 binding stabilises an active conformation that couples to G<sub>s</sub> and raises intracellular cAMP.}} |