Glucagon-like peptide-1: difference between revisions
Diff·revision 16 → 17·20:22, 19 Aug 2024
Difference between revision 16 and revision 17 of Glucagon-like peptide-1. 7 lines changed; the page grew by 569 bytes.
| Revision 16 — 18:41, 14 Aug 2024 ChromCleanupCass (talk) rv restoration of unsourced claim 4,861 bytes ±0 | Revision 17 — 20:22, 19 Aug 2024 GIP_Genoveva (talk) rv — see talk 5,430 bytes +569 | ||
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| 4 | | Precursor = [[Proglucagon]] (gene {{math|GCG}}) | 4 | | Precursor = [[Proglucagon]] (gene {{math|GCG}}) |
| 5 | | Principal source = [[Enteroendocrine L cell|Intestinal L cells]] | 5 | | Principal source = [[Enteroendocrine L cell|Intestinal L cells]] |
| + | 6 | <!-- Molecular data --> | |
| + | 7 | | Active forms = GLP-1 (7–37) and GLP-1 (7–36) amide | |
| + | 8 | | Residues = 31 (7–37) / 30 (7–36 amide) | |
| + | 9 | | Monoisotopic mass = ≈3,297 Da (7–36 amide) | |
| + | 10 | | Sequence position = Proglucagon 78–107 | |
| 6 | }} | 11 | }} |
| 7 | 12 | ||
| ⋮ | ⋮ | ||
| 16 | 21 | ||
| 17 | Cloning of the proglucagon gene in the early 1980s revealed two glucagon-like sequences downstream of glucagon itself, designated glucagon-like peptide-1 and glucagon-like peptide-2. The full-length GLP-1 (1–37) proved to be biologically inert; N-terminal truncation to GLP-1 (7–37) yielded a potent insulinotropic peptide.{{r|holst1987}} Physiological activity in humans was demonstrated shortly afterwards by infusion studies showing marked, glucose-dependent insulin release.{{r|kreymann1987}} | 22 | Cloning of the proglucagon gene in the early 1980s revealed two glucagon-like sequences downstream of glucagon itself, designated glucagon-like peptide-1 and glucagon-like peptide-2. The full-length GLP-1 (1–37) proved to be biologically inert; N-terminal truncation to GLP-1 (7–37) yielded a potent insulinotropic peptide.{{r|holst1987}} Physiological activity in humans was demonstrated shortly afterwards by infusion studies showing marked, glucose-dependent insulin release.{{r|kreymann1987}} |
| + | 23 | ||
| + | 24 | The residue numbering convention retained in the literature is that of the full-length peptide, which is why the active species is conventionally written GLP-1 (7–36) amide rather than renumbered from its own N-terminus. This is a persistent source of confusion in secondary sources, and articles on this wiki follow the conventional numbering. | |
| 18 | 25 | ||
| 19 | == Biosynthesis and secretion == | 26 | == Biosynthesis and secretion == |