Gastric emptying (revision 1)
Old revision·16:52, 1 Aug 2024·ProglucagonPia
This is an old revision of this page, as it stood at 16:52, 1 Aug 2024, saved by ProglucagonPia with the summary new article: incretin physiology, expansion welcome. It may differ substantially from the current revision, and any error it contains may since have been corrected.
| Gastric emptying | |
|---|---|
| Measured by | Scintigraphy, breath test, paracetamol absorption |
| Normal half-emptying time | ≈45–90 min for a solid meal |
| Effect of GLP-1 agonism | Delay, attenuating with continued exposure |
| Topic infobox · conventions | |
Gastric emptying is the rate at which the contents of the stomach are delivered to the duodenum. It is regulated by fundic tone, antral contraction and pyloric resistance, and is modulated by feedback from nutrients already in the small intestine — the mechanism by which Glucagon-like peptide-1 and other gut hormones slow it.[1]
Delayed emptying is one of the principal actions of GLP-1 receptor agonists. It blunts the postprandial glucose excursion by delivering carbohydrate to the absorptive surface more slowly, and it contributes to early satiety through gastric distension. In short-acting agonists it accounts for a substantial part of the postprandial glycaemic effect.[1]
References
Categories: