Gastric emptying: difference between revisions
Diff·revision 6 → 7·01:02, 6 Nov 2024
Difference between revision 6 and revision 7 of Gastric emptying. 5 lines changed; the page grew by 639 bytes.
| Revision 6 — 02:34, 13 Oct 2024 LCellLeif (talk) attribute the gastric-emptying effect to the study that measured it 3,153 bytes ±0 | Revision 7 — 01:02, 6 Nov 2024 AnalyticalAnnie (talk) sentence case in headings per PP:MOS 3,792 bytes +639 | ||
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| 19 | Measurement methods are not interchangeable. Scintigraphy is the reference technique; the ¹³C-octanoate breath test is a validated surrogate; paracetamol absorption is convenient but measures liquid-phase emptying only. A study reporting "delayed emptying" without naming its method is not comparable with one that names a different method. | 19 | Measurement methods are not interchangeable. Scintigraphy is the reference technique; the ¹³C-octanoate breath test is a validated surrogate; paracetamol absorption is convenient but measures liquid-phase emptying only. A study reporting "delayed emptying" without naming its method is not comparable with one that names a different method. |
| 20 | 20 | ||
| + | 21 | == Effect of incretin agonists == | |
| + | 22 | GLP-1 receptor agonism delays emptying through vagal pathways and through direct action on gastric smooth muscle, increasing fundic compliance and pyloric tone.{{r|drucker2018}} | |
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| + | 24 | The magnitude depends on the exposure profile. A short-acting agonist producing peaks and troughs delays emptying strongly at each peak; a continuously present long-acting agonist produces a delay that diminishes over weeks. The mechanism of that attenuation is thought to be receptor desensitisation on the relevant neurons, and it is one of the clearest examples of tachyphylaxis in incretin pharmacology.{{r|marathe2013}} | |
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| 21 | == References == | 26 | == References == |
| 22 | {{reflist}} | 27 | {{reflist}} |