Gastric emptying: difference between revisions
Diff·revision 14 → 15·12:04, 12 Jun 2025
Difference between revision 14 and revision 15 of Gastric emptying. 5 lines changed; the page grew by 606 bytes.
| Revision 14 — 02:35, 6 May 2025 EndotoxinEd (talk) expand §Normal physiology 4,652 bytes +16 | Revision 15 — 12:04, 12 Jun 2025 LCellLeif (talk) add the species in which the knockout work was done 5,258 bytes +606 | ||
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| 27 | Three clinical consequences follow. First, postprandial glucose control is contributed to differently by short- and long-acting agents.{{r|nauck2016}} Second, nausea correlates with the degree of delay, and the attenuation of the delay tracks the attenuation of nausea. Third, and more recently recognised, residual gastric contents after conventional fasting periods have prompted revised preoperative guidance; see [[Aspiration risk under anaesthesia]]. | 27 | Three clinical consequences follow. First, postprandial glucose control is contributed to differently by short- and long-acting agents.{{r|nauck2016}} Second, nausea correlates with the degree of delay, and the attenuation of the delay tracks the attenuation of nausea. Third, and more recently recognised, residual gastric contents after conventional fasting periods have prompted revised preoperative guidance; see [[Aspiration risk under anaesthesia]]. |
| 28 | 28 | ||
| + | 29 | == Interaction with oral drugs == | |
| + | 30 | Delaying emptying alters the absorption profile of oral medicines. For most drugs the effect is on rate rather than on extent, so total exposure is unchanged and the practical consequence is small.{{r|marathe2013}} | |
| + | 31 | ||
| + | 32 | It matters where the timing of a peak concentration is what produces the effect — analgesics taken for acute pain, for instance — and where a drug has a narrow therapeutic index and is dosed against a target concentration. The oral contraceptive and levothyroxine are the interactions most often examined; reported effects have generally been modest. | |
| + | 33 | ||
| 29 | == References == | 34 | == References == |
| 30 | {{reflist}} | 35 | {{reflist}} |