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Fasting insulin (revision 2)

Old revision·22:46, 21 Sep 2024·A1c_Alder

This is an old revision of this page, as it stood at 22:46, 21 Sep 2024, saved by A1c_Alder with the summary give the coefficient of variation with the level it was measured at. It may differ substantially from the current revision, and any error it contains may since have been corrected.
Fasting insulin
SpecimenFasting plasma or serum
InterpretableOnly alongside a simultaneous glucose
StandardisationPoor between assays
Topic infobox · conventions

Fasting insulin is the concentration of insulin measured after an overnight fast. It is widely available and widely over-interpreted: an insulin value alone answers no question, because the same concentration means different things at different glucose concentrations.[1]

Insulin immunoassays are poorly standardised between manufacturers, differing in cross-reactivity with proinsulin and its split products. Values from different laboratories are not interchangeable, and derived indices inherit the discrepancy.[1]

References

  1. ^ a b Wallace TM, Levy JC, Matthews DR. "Use and abuse of HOMA modeling." Diabetes Care 27(6):1487–1495 (2004). DOI:10.2337/diacare.27.6.1487. PMID 15161807.