Enteroendocrine L cell: difference between revisions
Diff·revision 13 → 14·22:23, 16 Sep 2024
Difference between revision 13 and revision 14 of Enteroendocrine L cell. 3 lines changed; the page grew by 425 bytes.
| Revision 13 — 23:54, 8 Sep 2024 GsCouplingGil (talk) split section 2,621 bytes ±0 | Revision 14 — 22:23, 16 Sep 2024 CiteBot (talk) bot: flag bare reference 3,046 bytes +425 | ||
|---|---|---|---|
| 10 | L cells express nutrient-sensing receptors including receptors for free fatty acids (particularly for long-chain and short-chain fatty acids), a glucose transporter for apical glucose sensing, and taste receptors. This array of receptors allows L cells to respond to a broad spectrum of luminal contents.{{r|holst2007}} | 10 | L cells express nutrient-sensing receptors including receptors for free fatty acids (particularly for long-chain and short-chain fatty acids), a glucose transporter for apical glucose sensing, and taste receptors. This array of receptors allows L cells to respond to a broad spectrum of luminal contents.{{r|holst2007}} |
| 11 | 11 | ||
| + | 12 | == GLP-1 synthesis and secretion == | |
| + | 13 | [[Proglucagon]], the precursor peptide, is expressed in L cells and processed post-translationally to generate GLP-1. Secretion is triggered by nutrient ingestion and follows a biphasic time course: an early phase (10–15 minutes) mediated by neural and hormonal signals from the proximal gut, and a later phase (30–120 minutes) as nutrients reach the distal intestine.{{r|holst2007}} | |
| + | 14 | ||
| 12 | == References == | 15 | == References == |
| 13 | {{reflist}} | 16 | {{reflist}} |