Dose escalation schedule: difference between revisions
Diff·revision 13 → 14·23:46, 8 Apr 2025
Difference between revision 13 and revision 14 of Dose escalation schedule. 3 lines changed; the page grew by 423 bytes.
| Revision 13 — 06:10, 17 Mar 2025 CiteBot (talk) bot: sort category members 3,650 bytes +18 | Revision 14 — 23:46, 8 Apr 2025 CarryOverCai (talk) state the number of doses a vial yields at that concentration 4,073 bytes +423 | ||
|---|---|---|---|
| 31 | Daily agents escalate weekly rather than monthly, for the same pharmacokinetic reason in reverse: steady state is reached in days, so a week is ample. The number of steps is similar; the calendar time is very different.{{r|wilding2021}} | 31 | Daily agents escalate weekly rather than monthly, for the same pharmacokinetic reason in reverse: steady state is reached in days, so a week is ample. The number of steps is similar; the calendar time is very different.{{r|wilding2021}} |
| 32 | 32 | ||
| + | 33 | These are the schedules used in the pivotal trials and reflected in product labelling.{{r|jastreboff2022}} The table is descriptive of published schedules; it is not guidance, and this wiki gives no dosing advice. | |
| + | 34 | ||
| 33 | == References == | 35 | == References == |
| 34 | {{reflist}} | 36 | {{reflist}} |
| ⋮ | ⋮ | ||
| 36 | <ref name="knudsen2019">Knudsen LB, Lau J. "The discovery and development of liraglutide and semaglutide." ''Frontiers in Endocrinology'' 10:155 (2019). PMID 31031702.</ref> | 38 | <ref name="knudsen2019">Knudsen LB, Lau J. "The discovery and development of liraglutide and semaglutide." ''Frontiers in Endocrinology'' 10:155 (2019). PMID 31031702.</ref> |
| 37 | <ref name="wilding2021">Wilding JPH, Batterham RL, Calanna S, et al. "Once-weekly semaglutide in adults with overweight or obesity." ''New England Journal of Medicine'' 384(11):989–1002 (2021). PMID 33567185.</ref> | 39 | <ref name="wilding2021">Wilding JPH, Batterham RL, Calanna S, et al. "Once-weekly semaglutide in adults with overweight or obesity." ''New England Journal of Medicine'' 384(11):989–1002 (2021). PMID 33567185.</ref> |
| + | 40 | <ref name="jastreboff2022">Jastreboff AM, Aronne LJ, Ahmad NN, et al. "Tirzepatide once weekly for the treatment of obesity." ''New England Journal of Medicine'' 387(3):205–216 (2022). PMID 35658024.</ref> | |
| 38 | 41 | ||
| 39 | == See also == | 42 | == See also == |