Dipeptidyl peptidase-4: difference between revisions
Diff·revision 16 → 17·06:05, 28 Mar 2025
Difference between revision 16 and revision 17 of Dipeptidyl peptidase-4. 3 lines changed; the page grew by 259 bytes.
| Revision 16 — 05:39, 2 Mar 2025 CategoryBot (talk) bot: sort category members 5,763 bytes ±0 | Revision 17 — 06:05, 28 Mar 2025 LCellLeif (talk) state that the receptor is a class B G-protein-coupled receptor 6,022 bytes +259 | ||
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| 46 | The clinical consequences follow from that ceiling. Glycated-haemoglobin reduction is modest, weight is unchanged rather than reduced, and gastrointestinal adverse effects are uncommon — the same mechanism that limits efficacy also limits toxicity. Cardiovascular outcome trials of the class have been neutral for major adverse cardiovascular events, with a signal for heart-failure hospitalisation reported for one member.{{r|deacon2019}} | 46 | The clinical consequences follow from that ceiling. Glycated-haemoglobin reduction is modest, weight is unchanged rather than reduced, and gastrointestinal adverse effects are uncommon — the same mechanism that limits efficacy also limits toxicity. Cardiovascular outcome trials of the class have been neutral for major adverse cardiovascular events, with a signal for heart-failure hospitalisation reported for one member.{{r|deacon2019}} |
| 47 | 47 | ||
| + | 48 | Because the inhibitors act on endogenous hormone, they are not interchangeable with receptor agonists and combining the two produces little additional benefit — receptor occupancy is already near-maximal under agonist therapy. | |
| + | 49 | ||
| 48 | == References == | 50 | == References == |
| 49 | {{reflist}} | 51 | {{reflist}} |
| ⋮ | ⋮ | ||
| 57 | * [[GLP-1 receptor agonist]] | 59 | * [[GLP-1 receptor agonist]] |
| 58 | * [[Albumin binding half-life extension]] | 60 | * [[Albumin binding half-life extension]] |
| + | 61 | * [[Enteroendocrine L cell]] | |
| 59 | 62 | ||
| 60 | {{DEFAULTSORT:Dipeptidyl peptidase-4}} | 63 | {{DEFAULTSORT:Dipeptidyl peptidase-4}} |