Arcuate nucleus (revision 1)
Old revision·09:00, 17 Sep 2024·MetricMabel
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| Arcuate nucleus | |
|---|---|
| Location | Mediobasal hypothalamus, adjacent to the median eminence |
| Anorexigenic population | POMC and CART neurons |
| Orexigenic population | AgRP and NPY neurons |
| Topic infobox · conventions | |
The arcuate nucleus is a region of the mediobasal hypothalamus containing two functionally opposed neuronal populations that regulate food intake: neurons expressing pro-opiomelanocortin (POMC), which suppress intake, and neurons expressing agouti-related peptide (AgRP) and neuropeptide Y, which promote it.[1]
Its position adjacent to the median eminence, where the capillaries are fenestrated, gives it unusual access to circulating signals. Hormones that cannot cross an intact blood-brain barrier can nonetheless influence arcuate neurons, which is why the nucleus is a principal target for peripherally administered peptides including GLP-1 receptor agonists.[1]
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